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Glial Fibrillary Acidic Protein (GFAP)

Methodology

IHC

Specimen Requirements

To perform IHC testing, we request formalin-fixed, paraffin-embedded tissue samples. Please ensure that the blocks are clearly labeled with the patient name or identifier, date of birth and type of sample (tumor, normal). Additionally, a copy of the pathology report accompanying the tissue block will be very helpful. If tissue blocks are not available, we will also accept unstained slides (please submit 1-2 slides per antibody to be tested, cuts must be 4 microns thick).

Clinical Significance

GFAP is the major protein found in astrocytes and its expression is evidence of astroglial origin and differentiation. Gliomas are the most common cerebral neoplasm in adults and include astrocytomas, oligodendrogliomas and glioblastomas. It can also be demonstrated in ependymal cells, ependymomas, subependyomas, glioblastomas, mixed central nervous system neoplasms and gangliomas. It is detected in immature but not mature oligodendrocytes and neurons. Anti-GFAP antibodies do not cross-react with neurons, fibroblasts or muscle cells. Anti-GFAP antibodies are useful in differentiating primary gliomas from metastatic lesions in the brain and for documenting astrocytic differentiation in tumors outside the central nervous system.

CPT Code(s)

88342

Turnaround Time

24 Hours

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