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5q deletion

Unfavorable prognosis. Among the most frequent cytogenetic abnormalities in leukemia and MDS. ...

7q deletion

Unfavorable prognosis. Detected in both de novo and secondary AML and MDS.; Unfavorable prognosis. ...

11q deletion

Unfavorable prognosis in CLL. Leukemia/Lymphomas with deletion of 11q, including the ATM gene, ...

13q deletion

The detection of 13q14.3 deletion is often observed in B-cell chronic lymphocytic leukemia ...

17p deletion

Unfavorable prognosis in CLL. Detected in 10-15% of B-CLL patients by FISH. Unfavorable prognosis ...

20q deletion

Detected in PV cases with chromosomal abnormalities.; Diagnostic for AML and MDS, depending ...

AML1/ETO, t(8;21)

Detected in about 40% of AML. Patients are predominantly younger, with a mean age of 30. The ...

BCL2 Rearrangement

Used in the diagnosis of MALT lymphoma, an extranodal marginal zone B-cell lymphoma. BCL2 expression ...

BCL6 Rearrangement

Chromosomal translocations involving chromosome 3q27 at the site of the BCL6 gene are observed ...

BCR/ABL

Diagnostic for CML and also seen in a subset of ALL and AML. In adult ALL and AML.

CBFB Rearrangement

Diagnostic for AML-M4Eo. Often associated with marrow eosinophilia. Detected in about 10-12% ...

CLL/SLL FISH Profile

Chronic lymphocytic leukemia (CLL) is associated with a variety of different chromosomal aberrations. ...

CML

CML patients have a unique molecular characteristic of the disease that causes an ABL (9q34) ...

EGFR

The FISH assay detects gene copy number of EGFR gene. The assay uses probes to a unique DNA ...

HER-2 (ERRB2), PathVysion®

The PathVysion® HER-2 DNA Probe Kit (PathVysion Kit) is designed to detect amplification of ...

IGH Rearrangement

Immunoglobulin heavy chain (IgH) rearrangement can be identified in about 70% of DLBCL cases.

IGH/BCL2

IGH/BCL2 is seen in about 75% of follicular lymphoma (FL) and 15-30% of diffuse large B-cell ...

IGH/CCND1

Diagnostic for MCL. Stratifies patients as likely mantle cell lymphoma (MCL). Usually associated ...

IGH/MALT1

Unfavorable prognosis. Found in about 20% of MALT. Significantly associated with H pylori.

IGH/MYC

Found in about 15% of MM cases. Usually associated with an unfavorable prognosis.

MALT1 Rearrangement

(Summary Not Avalilable)

MDS FISH Profile

At diagnosis, approximately half of myelodysplastic (MDS) patients can present a normal karyotype ...

MLL Rearrangement

Intermediate to poor prognosis. There a numerous 11q23 translocation variants, the more common ...

MYC Rearrangement

In Burkitt lymphoma, the translocation t(8;14)(q24.1;q32) is present in 75-80% of all cases.

NHL FISH Profile

Several types of non-Hodgkin lymphoma are associated with specific, recurring cytogenetic abnormalities ...

Plasma Cell Neoplasm/Myeloma FISH Panel

The cytogenetics of multiple myeloma (MM) can be highly complex. A number of non-random numerical ...

PML/RARA

Diagnostic for AML-M3 (also known as Acute Promyelocytic Leukemia). Detected in about 5-8% ...

RARA Rearrangement

Diagnostic for acute promyelocytic leukemia. Determines rearrangement of retinoic acid receptor ...

Trisomy 3

Associated with hyperdiploid MM.

Trisomy 7

Associated with hyperdiploid MM.

Trisomy 8

Detected in PV and IMF cases with chromosomal abnormalities. Intermediate prognosis in MDS. ...

Trisomy 9

Associated with hyperdiploid MM.

Trisomy 11

Multiple myeloma (MM) is characterized by complex cytogenetics and aneuploidy in almost all ...

Trisomy 12

Unfavorable prognosis. Found in about 20% of CLL/SLL cases. Associated with a predominantly ...

UroVysion®

The UroVysion® Bladder Cancer Kit (UroVysion Kit) is designed to detect aneuploidy for chromosomes ...

X,Y Chromosome Analysis

The X/Y FISH assay may be used to evaluate engraftment success in recipients of sex mismatched ...