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CA15-3

CA15-3 has been detected in a wide spectrum of carcinomas such as breast carcinomas including ...

CA19-9

In normal tissues, the CA19-9 antigen has been demonstrated in ductal epithelium of the breast, ...

CA-125

CA-125 reacts with approximately 80% of epithelial ovarian neoplasms of serous, endometrioid, ...

Calcitonin

Calcitonin is secreted by thyroidal parafollicular cells of neuroectodermal origin, probably ...

Caldesmon

Caldesmon is a developmentally regulated protein involved in smooth muscle and non-muscle contraction. ...

Calponin (CALP 1)

Calponin, a calmodulin, is involved in the regulation of smooth muscle contraction. The expression ...

Calretinin

Calretinin is the most specific and reproducible positive marker of epithelial mesothelioma. ...

Carbonic Anhydrase IX

Carbonic anhydrase IX (CAIX) is a cell surface transmembrane protein, which is predominantly ...

Carcinoembryonic Antigen (CEA) Monoclonal

CEA is usually demonstrated as a linear labeling of the apical poles of cells lining the glandular ...

Carcinoembryonic Antigen (CEA) Polyclonal

Polyclonal CEA stains a larger percentage of Cholangiocarcinomas compared with Hepatocellular ...

Caspase 3

Designed to provide information on cell death vs. cell proliferation rates.

Cathepsin D

Prognostic marker in many tumor types, especially breast cancer.

CBFB Rearrangement

Diagnostic for AML-M4Eo. Often associated with marrow eosinophilia. Detected in about 10-12% ...

CD1a

Cortical thymocytes. Used for diagnosis of Langerhans cell histiocytosis and exclusion of other ...

CD1a

At least five CD1 genes (CD1a, b, c, d, and e) have been identified. CD1a is expressed on cortical ...

CD2

Thymic and peripheral T-cells, NK cells. An early T-cell marker. Used as a T-cell marker and ...

CD2

CD2, the E-rosette receptor, is an extremely broad T-cell marker. This antibody immunolabels ...

CD3

The CD3 antigen is first detectable in early thymocytes and its appearance probably represents ...

CD3

Pan T-cells. Required for TCR cell surface expression and signal transduction. Positive for ...

CD4

Helper T-cells, thymocyte subset, monocytes. Expressed on surface of T-helper cells. Serves ...

CD4

CD4, a single chain transmembrane glycoprotein, is found on a T-cell subset (helper/inducer). ...

CD5

Pan T-cells, mature B-cell subset (B1a cells). Used as a marker for CLL, mantle cell lymphoma, ...

CD5

CD5, a transmembrane protein, is found on most thymocytes and immature peripheral T-cells. ...

CD7

Thymic and peripheral T-cells, NK cells. Plays important role in T-cell, B-cell interaction ...

CD7

CD7 is expressed on the majority of immature and mature T-lymphocytes and T-cell leukemia. ...

CD8

CD8 is a T-cell marker for the detection of cytotoxic/suppressor T-cells. CD8 is also detected ...

CD8

Suppressor T-cells, NK cells, thymocyte subset. Associated with lymphoepithelioma-like carcinoma ...

CD10

Follicle center B-cells, CALLA, myeloid subset. Used to identify acute lymphoblastic leukemia ...

CD10

CD10, also known as Common Acute Lymphocytic Leukemia Antigen (CALLA), is expressed in early ...

CD11b

Monocytes/macrophages, dendritic, granulocytes, NK cells. A marker for myeloid differentiation. ...

CD11c

Monocytes, myeloid subset, hairy cell leukemia. Used for histiocytic marker, NK cell marker, ...

CD11c

Useful in identification of cells of the macrophage/dendritic cell lineage in tissue.

CD13

Myeloid cells, monocytes. CD13 autoantibodies are strongly associated with chronic graft versus ...

CD14

Mature monocytes. Used to identify mature monocytes/macrophages. Positive in B-CLL, follicular ...

CD15

CD15 (X-Hapten) plays a role in mediating phagocytosis, bactericidal activity, and chemotaxis. ...

CD15

Used to confirm diagnosis of Hodgkin lymphoma, help differentiate between Hodgkin lymphoma ...

CD16

Granulocytes, NK cells

CD19

Detection of CD19 expressing cells is important in the diagnosis of leukemic precursor B cells ...

CD19

Labels B-cells in normal and neoplastic tissue.

CD20

Positive staining (normal): Most B-cells (after CD19 and CD10 expression, before CD21/22 expression ...

CD20

Pan B-cells. Commonly used as a marker for B-cells. Positive in 90% of B-cell lymphomas, B-CLL, ...

CD21

CD21 (CR2, C3d receptor and EBV receptor) is expressed strongly on mature B-cells, follicular ...

CD22

CD22 expression is restricted to normal and neoplastic B-cells and is absent from other hemopoietic ...

CD22

Recognizes most B-cells. Used as a pan B-cell marker; diagnosis of hairy cell leukemia, Aberrant ...

CD23

CD23 is identical to low affinity IgE receptor found on B-cells. CD23 is expressed on a subpopulation ...

CD23

Mature B-cells, CLL. A dendritic cell marker. Mantle cell lymphoma is usually CD23 negative, ...

CD25

The interleukin-2 receptor is designated CD25. Originally isolated from T-lymphocytes, it ...

CD25

Activated T and B-cells, hairy cell leukemia. High levels by flow cytometry are associated ...

CD30

CD30 is a lymphocyte activation antigen, related to tumor necrosis factor. Positive staining ...

CD31

CD31 is a 130-kd transmembrane glycoprotein that is shared by vascular lining cells, megakaryocytes ...

CD33

Useful for identification of cells for myeloid and monocytic lineage, leukemias and myeloproliferative ...

CD33

Myeloid cells, monocytes. Used to distinguish myeloid and lymphoid leukemia; identify monocytes ...

CD34

CD34, a single chain transmembrane glycoprotein, is selectively expressed on human lymphoid ...

CD34

Precursor cells. Defines adult hematopoietic stem cells. In AML, detection of CD34+ cells by ...

CD35

CD35 antigen is a transmembrane protein of 160-250 kD that binds complement components C3b ...

CD38

Activated T, B, myeloid cells, B-cell subset. Presence on 30% or more B-CLL cells by flow cytometry ...

CD38

CD38 is a transmembrane protein, that is highly expressed on thymocytes. It is also present ...

CD41

Fibrinogen receptor, von Willebrand factor (vWf), platelets and megakaryocytes. A receptor ...

CD42b

Expressed on megakaryocytes, platelets and their precursors.

CD43

CD43 (leukosialin, sialophorin, or leukocyte sialoglycoprotein) is a cell surface glycoprotein ...

CD45

CD45 (Leukocyte Common Antigen, LCA) is comprised of at least four isoforms (CD45RA, CD45RB, ...

CD45

Leukocyte common antigen. An essential regulator of T- and B-cell antigen receptor-mediated ...

CD45RB

Expressed on mature B-lymphocytes and a majority of lymphomas and leukemias of B-cell origin.

CD45RO

CD45RO (an isoform of leukocyte common antigen) reacts with mature activated T-cells, most ...

CD56

CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed ...

CD56

T-cell subset, NK cells. Prototypic marker of NK cells, also present on subset of CD4+ and ...

CD57

T-cell subset, NK cells. May define a phenotype associated with replicative senescence in HIV ...

CD57

CD57 is expressed on a subpopulation of 15-20% of peripheral blood mononuclear cells, about ...

CD61

CD61 (GPIIIa) is a glycoprotein found on megakaryocytes, platelets and their precursors. CD61 ...

CD61

Glycoprotein IIIa, Integrin ß-3, Megakaryocytes, Platelets. Combines with CD41 (integrin alpha ...

CD64

Monocytes, myeloid subset. Positive staining for AML-M3 (usually); M4, M5, M0-M2 (variable). ...

CD68

CD68 is important for identifying macrophages in tissue sections. It stains macrophages in ...

CD71

Transferrin Receptor, Activated T- and B-Cells, Macrophage. Present on actively proliferating ...

CD74

Expression of the invariant chain of the HLA-DR antigen (CD74) by B-lymphocytes begins in ...

CD74

CD74 is expressed primarily by antigen presenting cells such as B lymphocytes (from before ...

CD75

The CD75 protein has a molecular weight of approximately 53kD and is a marker of mature B- ...

CD79a

CD79a first appears at the pre B-cell stage and persists until the plasma cell stage where ...

CD79a

B-cells, plasma cells. Expressed early in B-cell differentiation, also expressed in plasma ...

CD99

CD99 (MIC2 gene product, E2) antigen is strongly expressed by Ewing’s sarcoma cells, primitive ...

CD103

CD103 is expressed on mucosa-associated T-lymphocytes and activated cells. This human intra ...

CD117

Stem cell receptor (c-kit), myeloid cells. Positive staining for AML, angiomyolipoma, angiosarcomas ...

CD123

Labels the plasmacytoid predendritic cells and may be helpful in diagnosing the Kikuchi-Fujimoto ...

CD138

CD138 (Syndecan-1) mediates cell adhesion, growth factors. Positive staining (normal): B-cell ...

CD138

CD138 plays a role in cellular proliferation and cell to cell adhesion. It expression is reduced ...

CD163

CD163 antigen is restricted in its expression to the monocytic/macrophage lineage. It is present ...

CDX2

CDX2 is an intestine specific transcription factor that regulates both the proliferation and ...

CDX2/CK7 Double Stain

CDX2 is a homeobox gene that encodes an intestine-specific transcription factor. It is expressed ...

CEACAM5

CEACAM5 (CEA-related cell adhesion molecule 5, CEA) belongs to the carcinoembryonic antigen ...

Chromogranin A

Chromogranin is present in several elements of the diffuse neuroendocrine system (DNES), including ...

Circulating Tumor Cell Analysis

The presence of circulating tumor cells (CTCs) in the blood of patients newly diagnosed with ...

C-KIT

CD117 (c-kit) is a transmembrane receptor tyrosine kinase. It binds to stem cell factor (SCF). ...

CLL/SLL FISH Profile

Chronic lymphocytic leukemia (CLL) is associated with a variety of different chromosomal aberrations. ...

CML

CML patients have a unique molecular characteristic of the disease that causes an ABL (9q34) ...

Collagen IV

Collagen IV is a major constituent of the basement membranes along with laminins and enactins. ...

CXCR4

CXCR4 is required to initiate proliferation and/or promote survival of breast cancer cells ...

Cyclin E

Cyclin E is a regulatory subunit of cdk-2 and controls G1/S transition during the cell cycle. ...

Cyclooxygenase-2

COX-2 is expressed in normal brain and kidney, activated macrophages, synoviocytes during inflammation ...

Cytogenetics

In some forms of cancer, especially hematological malignancies, cytogenetics can determine ...

Cytokeratin - (CK - HMW/LMW) Double Stain

This cocktail can be useful in differentiation of the squamous cell carcinomas and adenocarcinomas. ...

Cytokeratin - High Molecular Weight

CK 903 (34betaE12) is a high molecular weight cytokeratin that reacts with all squamous epithelium ...

CYTOKERATIN 5

CK5 is a 58 kDa protein that is closely related to CK6. CK5 tissue distribution is in many ...

Cytokeratin 5/6

CK5/6 positivity is seen in nearly 100% of malignant mesotheliomas and in almost no lung adenocarcinomas. ...

Cytokeratin 7

This antibody reacts with proteins that are found in most ductal, glandular and transitional ...

Cytokeratin 8

Cytokeratin 8, 35betaH11 antibody, is reactive with the majority of epithelium and epithelial ...

Cytokeratin 14

CK14 belongs to the type A (acidic) subfamily of high molecular weight keratins and exists ...

Cytokeratin 17

CK17 is an excellent marker to distinguish myoepithelial cells from luminal epithelium of various ...

Cytokeratin 18

Stains most epithelial-derived tumors.

Cytokeratin 19

Cytokeratin 19 is a member of type I acidic subfamily of keratins. It is expressed in various ...

Cytokeratin 20

CK20 positivity is seen in the majority of adenocarcinomas of the colon, mucinous ovarian carcinomas, ...

Cytokeratin AE1/AE3 (Pan)

Monoclonal antibodies AE1 and AE3 recognize the acidic and basic subfamilies of cytokeratin ...

Cytokeratin CAM 5.2

Anti-Cytokeratin (CAM 5.2) has a primary reactivity with human keratin proteins that correspond ...

Cytokeratin OSCAR

CK OSCAR demonstrates a broad spectrum of cytokeratin reactivity. In normal tissues, OSCAR ...

Cytomegalovirus

Cytomegalovirus (CMV) is an opportunistic pathogen infecting lung, kidney, gut and other organs ...

Cytoplasmic Immunoglobulin G (IGG)

Immunoglobulin G heavy chain

Cytoplasmic Kappa Light Chain Immunoglobulin

Kappa Ig light chain, B-cells, plasma cells

Cytoplasmic Lambda Light Chain Immunoglobulin

Lambda Ig light chain, B-cells, plasma cells