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Ki-67

Methodology

IHC

Specimen Requirements

To perform IHC testing, we request formalin-fixed, paraffin-embedded tissue samples. Please ensure that the blocks are clearly labeled with the patient name or identifier, date of birth and type of sample (tumor, normal). Additionally, a copy of the pathology report accompanying the tissue block will be very helpful. If tissue blocks are not available, we will also accept unstained slides (please submit 1-2 slides per antibody to be tested, cuts must be 4 microns thick).

Clinical Significance

Ki-67 is a nuclear protein that is expressed in proliferating cells. Ki-67 is preferentially expressed during late G1-, S-, M-, and G2-phases of the cell cycle, while cells in the G0 (quiescent) phase are negative for this protein. Increased proliferative activity is associated with more aggressive tumor and decreased disease-free survival period.

CPT Code(s)

88342

Turnaround Time

24 Hours

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